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. The high response of tetrameric proteins may suggest a particular destabilization of the native structure associated to the oligomeric state, a perturbation probably related to dissociation of the subunits and exposure of previously buried hydrophobic regions
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. In the large oocytes of the frog Xenopus laevis, this was small enough to allow the recording of the first compartment-selective in vivo MR spectra from the animal and vegetal cytoplasm as well as the nucleus
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. Lipid suppression has been especially important for selecting regions for localized spectroscopy, since at this high magnetic field strength, the lipid image of the lipid-rich oocyte significantly affects the water image, thus hampering correct voxel positioning
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. Notwithstanding these experimental results, we were not able to detect any differences in global MSDs between DmAChE and HuBChE, despite the former having a much lower degree of glycosylation than the latter
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.Key words: asthma; COPD; cystic fibrosisAbbreviations: CF = cystic fibrosis; CFTR = cystic fibrosis transmembrane regulator; Gas6 = growth-arrest-specific-factor 6; GTPase = guanosine triphosphatase; HGF = hepatocyte growth factor; IL = interleukin; LRP = lipoprotein receptor-related protein; MFG = milk-fat-globule-factor; PPAR = peroxidase proliferator-activated receptor; PS = phosphatidylserine; PSR = phosphatidylserine receptor; SP = surfactant protein; TGF = transforming growth factor; TNF = tumor necrosis factor; VEGF = vascular endothelial growth factor**********Cell death, removal, and replenishment are increasingly recognized as fundamental processes in both the developing and the developed organism
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.The influence of inhibitor-binding on global enzyme molecular dynamicsAlthough several studies using different techniques have shown a modification of global protein molecular dynamics on an Ångström-nanosecond scale upon inhibitor-binding, we were not able to detect any significant differences between the native and the inhibited HuBChE, at comparable degrees of hydration, up to ~334 K (61°C)
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