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. Folding of the four domains and dimerization are impaired by the G/y446-Glu exchange in human glutathione reductase
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. It was difficult to distinguish in this research whether the pretransitional changes occurred in the catalytic domain or the dimerization domain of ACYI
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. This suggests that the oligomannose glycan is well embedded in the clefts and cavities on the protein surface
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. Although R^sub g^ scales with chain length as N^sup 0
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. Analysis of the pH- and thermal-denaturation curves The fittings to Eqs
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. We extracted MSDs only from the smaller Q-range, 0
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. 5) to transform cooperatively into hierarchically twisted features (Fig
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. Partitioning the configurational space in this way, and by providing an attractive "gutter", relying on local forces alone, to connect one diffusive subspace to the next, creates the advantageous funnel landscape when the high-dimensional structure is projected into a one- or two-dimensional space
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. We now take a much simpler fold as an example
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. Little information can be extracted by comparing the entropy of the two states
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. This may reflect the large structural change and the crossing of the free and bound buildup curves (Fig
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. In contrast to the compact CD4, gp120 undergoes a number of significant loop contractions and translocations upon CD4 binding, which occur on a more extended timescale than the high-frequency local fluctuations
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. Isopar G, H, and L contain hydrocarbons with 10-11, 11-12, and 11-13 carbon atoms, respectively, and were used as received
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. **********Many fish species in the North Pacific have a long reproductively active life span, which increases the likelihood of producing offspring during periods of favorable environmental conditions
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. At each step of the surgical procedure, details of the instruments used with the advantages and disadvantages of each particular type is outlined
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. When used according to labeling instructions, acetaminophen has an excellent safety profile; however, acetaminophen toxicity may occur after intentional overdose or acute ingestion of approximately 150 mg to 250 mg of acetaminophen per kilogram of body weight--the equivalent of 15 to 28 extra-strength tablets for a 155-pound person
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. Due to its crucial physiological role, AChE is the target of nerve agents and insecticides, as well as of the first generation of anti-Alzheimer medications (for literature, see (20))
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. Greater densities (>20 larvae/10 [m
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. Comparison of the configurational entropies of gp120 and the CD4 D1 domain (denoted CD4 for simplicity in the following) in the free and bound states suggests that the formation of intermolecular hydrogen bonds and hydrophobic contacts contributes most to the entropy changes
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. This suggests that two slightly different conformational spaces are sampled in the free and complex forms of the molecule, representing a situation of case A (Fig
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. 10), as well as an upper limit on the intrinsic statistical broadening of the FRET histograms due to shot noise (Deniz et al
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