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. © 2007 by the Biophysical Society 0006-3495/07/01/578/10 $2
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.For studies of conformational exchange it is important to ascertain whether the exchange is in the fast or slow exchange limit
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. A decrease in conformational entropy after appending a second trajectory that samples a much smaller conformational space than the first one, and is contained in the conformational space of the first trajectory (Fig
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