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Reversibility of the thermal transition was examined by reheating the samples after cooling from the first scan
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The 2D IR plots were presented as contour maps produced by drawing the contour lines every 10% off from the maximum intensity of the whole correlation map
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Changes in the CD signal at 208 nm (where the parallel polarized π-π* transition occurs) are the result of a flexibility of the structure (46)
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Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells
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A similar difference in emission peak maxima between thermal and GndHCl-induced unfolding was also observed for other proteins (see for example (10,21))
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Since IENS averages 730 ps in our experiments over the total instrumental resolution time, it is possible that putative dynamical differences of opposite sign, on shorter timescales of ~10 ps, might simply have been cancelled out
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Stabilization of proteins by glycosylation examined by NMR analysis of a fucosylated proteinase inhibitor
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Hence, there are four hinge regions in the CaM dimer
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CONSEQUENCES OF HIGH-DIMENSIONAL SEARCHESWe have identified two general predictions of this high-dimensional view of folding: 1), the sequential diffusive exploration of low-dimensional subspaces favored by fast folding; and 2), the suggestive stabilization of these subspaces by discriminate but nonnative (or near-native) interactions, without recourse to long-range guiding forces
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The individual fatty acids have specific functional properties related to health
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Nonbonded interactions were calculated using twin-range cutoffs of 0
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Entropy estimation from simulations of non-diffusive systems
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