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Here, a^sub o^ is a normalization constant, which ensures that ∫^sup ∞^^sub 0^ 4πx^sup 2^P(x)dx = 1
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It may also be possible that a smaller degree of subunit dissociation in part explains the sharp increase in the residual enzymatic activity, retained after freeze-thawing, with increasing protein concentration (14,16,29)
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^sup 1^H NMR visible lipids in the life and death of cells
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To contribute to the ongoing discussion and to investigate the relationship among molecular dynamics, activity, inhibitor-binding, and unfolding, we carried out incoherent elastic neutron scattering experiments on two members of the cholinesterase (ChE) family: Tetrameric human butyrylcholinesterase (HuBChE), both native and covalently inhibited by the organophosphate nerve agent, soman (18), and dimeric native Drosophila melanogaster acetylcholinesterase (DmAChE)
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For example, it has recently been shown that the simulated packing of ellipsoidal particles showed a dependence on aspect ratio and can approach a packing, φ^sub max^, of ~0
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A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy
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Furthermore, information on the effect on folding rate of replacing specific residues via mutation or "Φ-value" analysis (Fersht, 2000) needs to be taken together with correlations of contact order
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Contamination of the machine is controlled by using a responsive mixing system
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Such analysis nonetheless enables us in the current study to estimate the entropic contribution of subsets of atoms, or degrees of freedom of interest, down to residue and atomic levels
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In summary, our comparative study of different ribozyme constructs shows that in contrast with the 2WJ and the 3WJ, the natural 4WJ architecture can efficiently guide conformational search events during ribozyme folding, thereby dramatically influencing subsequent tertiary structure formation and stability
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