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However, those authors propose that this phenomenon is unlikely to have physiological relevance, since the inactivation of GR is very slow at cellular NADPH concentrations
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Besides, complex formation between GR and NADPH was only detected in the dimeric form of the enzyme, which would argue that NADPH does not participate directly in the process of GR folding/assembly
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Positive crosspeaks could be found at (1649 cm^sup -1^, 1636 cm^sup -1^), and negative crosspeaks were located at (1649 cm^sup -1^, 1617 cm^sup -1^) and (1658 cm^sup -1^, 1617 cm^sup -1^)
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[FIGURE 1 OMITTED]While Type 2 RP appeared to have little effect on the total volume of NSAIDs dispensed, it did have a substantial effect on reimbursement prices (see Figure 2 and Table 2)
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. On the basis of our results, we propose that assembly of the native GR dimer proceeds via initial formation of MG monomers that dimerize to form a partially folded, expanded dimer
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