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Of the numerous roles credited to glycosylation the major ones are to facilitate proper folding, prevent protein aggregation, protect against proteolytic attack, and act as surface cell receptors and targeting signals (4,5)
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Reference deleted in proof
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the tertiary structure of EI^sup sc^ remained unaltered, as suggested by fluorescence and ANS-binding (Fig
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) sponsored by Pfizer Inc, and by grants from the National Institutes of Health grants HL072018 (R
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The remaining native fraction after 15 freeze-thawing cycles is listed in Table 1 where it is compared to the respective values of n and average dissociation constant K^sub d^
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Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties
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The translational entropy of counterions and a hydration effect play important roles in this process
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Li+ shows moderate chemical potential in PEG 3000 but is the weakest DNA compaction agent in PEG 10000
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The Trp fluorescence of acid unfolded TTR peaks at 352 nm (data not shown) compared to 340 nm in the native protein, indicating unfolding
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These include, but are not restricted to, native and near-native hydrophobic side-chain interactions
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More detailed predictions of nonnative contributions to Φ for the family of bacterial immunity proteins and their mutants are in accord with very recent experiments
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HAND AND NAIL CAREORLY TOP 2 BOTTOM 0
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023-55,344 -4,279Effect of Type 2 RPNSAIDsAverage monthly effect -38
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A pointed example of this practice is the mind-boggling consumption of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)--causing potentially life-threatening damage (ulcers, intestinal bleeding, stroke, cataracts, kidney failure, liver damage, high blood pressure) when used long-term
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My suggestion that this profile also described a business traveler elicited incredulous silence
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"It's the pharmacist talking to the consumer," Painter said
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Prescription sales at Wal-Mart account for an estimated 4 percent of total revenues
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Besides a public policy forum and an update on Medicare reform from Leslie Norwalk, deputy director of CMS, the roughly 1,250 independent pharmacy representatives in attendance also got a look at the offerings of more than 300 trade show exhibitors
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That's our 'value add' at Wal-Mart
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In turn, those cost-cutting efforts have triggered a widespread backlash and education effort among the nation's chain and independent pharmacies, as industry leaders and pharmacy organizations wage a determined campaign in dozens of states to keep pharmacy off the chopping block and deflect the budget-cutter's axe
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But does this mean the proliferation of legalized gambling has transformed us from productive, hard-working Puritans into incorrigible gluttons of chance? Or are we simply expressing appetites we've had all along?A Nation of High Rollers"Now we see," Wolf complains at the Sheraton, "as if our nation isn't saturated enough with gambling, a group of investors this spring has announced plans to try to open a casino two miles from historic Gettysburg
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As any contemporary gambling booster will tell you, Jamestown, the first permanent English settlement in North America, was underwritten by a lottery conducted in London by the Virginia Company
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ANNE RILEY-KATZStaff Reporter
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