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. Thus, the value for K^sub SV^ will depend on the particular average intrinsic fluorescence lifetime of the protein, and may be higher than the value for free Trp
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. The precipitate was resuspended m 6 M guanidinium hydrochloride (in 10 mM Tris buffer (pH 7
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. The spectra were collected at a scan speed of 50 nm min^sup -1^
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. The helix-loop-helix motif formed by the α-helix 9-α-helix 10 shows intermonomer salt bridges: Asp^sup 540^ in the motif with Arg^sup 422^' in α-helix 5 from the other monomer (the prime is used to designate residues in the other monomer)
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. Taking advantage of the subcellular resolution now achieved with MRS, we examined, upon drug delivery, the spectroscopic changes in the three subcellular compartments of the Xenopus oocyte over time
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. Although the other monocations may be involved with DNA binding solely through electrostatic force, there may be some other possibilities with Li+ ion, and the position of Li+ ion in this monocation activity sequence seems to depend strongly on the detection method and experimental conditions
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. Acetone and Isopar solvents are miscible, but methanol and Isopar solvents are not
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. Groups registered under section 501c of the tax code aren't required to disclose their donors, but they're also not supposed to make electioneering their main activity
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. Because of the linkage, it is possible that a genetic mutation that improves metabolism could also harm eye development, or be linked to a gene that does
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. Local stiffness is typically quantified in terms of a persistence length, which is the length scale over which the chain behaves like a rigid rod (40,79)
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.36) which evaluates the properties of the structure, such as the atomic contact map
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. This time the story is of a Spanish man forced to sell his virtual-reality theme park
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. Apparent mitochondrial asymmetry in Xenopus eggs
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.0 do not support this explanation (Fig
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. Interestingly, the β-sheet content is higher in the A-state than in native TTR, although some loss of contribution from aromatic residues such as Trp also could influence the intensity of the far-UV CD signal (Freskgård et al
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.LipidsAll lipids were purchased from Avanti Polar Lipids (Alabaster, AL)
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., 1999), but which do not bear an interpretation in terms of native structure (Fersht, 1999)
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. Temperature values in parentheses indicate thatonly surface temperature was registered
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.We note here that although we have interpreted peak shifts and broadening in terms of distance changes and ribozyme subpopulations, respectively, peak shifts could also potentially be caused by solvent effects on dye photophysics, and corresponding changes in the correction factor [gamma] (see Materials and Methods), as well as peak broadening by effects of [kappa]^sup 2^, the orientation factor (Deniz et al
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. In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development
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.Besides a public policy forum and an update on Medicare reform from Leslie Norwalk, deputy director of CMS, the roughly 1,250 independent pharmacy representatives in attendance also got a look at the offerings of more than 300 trade show exhibitors
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