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379 Mathnasium LearningNo NoCenters404 Oxford LearningNo NoCenters Inc
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DATA ANALYSIS DISCUSSION It is reasonably clear that the presence of glycosylation does affect the expression of the protein into its final mature form
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8, B and C, underscore the importance of conformational fluctuations
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There have been numerous attempts to develop models for conformations accessible to highly denatured proteins
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Helix-Loop-Helix (HLH) transcription factors regulate numerous developmental processes (12,13)
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This shows that liquid-liquid separation occurs in a region of the phase diagram which is metastable with respect to solid-liquid phase separation
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Such work is ongoing in our laboratories, and data from misfolded TTR oligomers recorded from site-specific fluorescence labeling of cysteine mutants have provided size distributions with average rotation correlation times of ~ 150 ns (K
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The particles have heights of 1
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Toward an outline of the topography of a realistic protein folding funnel
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Using MD simulations we have identified concerted loop motion around the CD4 binding site in gp120 upon binding (Hsu and Bonvin, 2004)
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Although in some cases, conventional structural parameters such as atom-positional fluctuations may fail to identify thermodynamic differences between two states, the conformational entropy analysis of combined trajectories can provide a complementary way of evaluating spatial distributions and their statistical weight
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The RNA strands were deprolected, purified by denaturing urea gel elcctrophoresis, desalted and subsequently purified by reversed-phase high-performance liquid chromatography utilizing an eluent system of acetonitrile and aqueous triethylammonium acetate (100 mM, pH 7)
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