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. For the neutron scattering experiments in which native and soman-inhibited HuBChE were compared, hydration of the dry samples was carried out by D^sub 2^O vapor exchange during 2-3 days over pure water (= 100% relative humidity) at 25°C
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. NOE values were determined from pairs of spectra recorded interleaved with and without a 4-s proton saturation (see Supplementary Materials, Table RS1, for more details)
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. The error in the R^sub 1^ and R^sub 2^ values was defined as the standard deviation between three curve fittings, one with all time points and two fittings with reduced data sels containing every second time point, which were shifted either zero or one time point in the relaxation series
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. Principles of Fluorescence Spectroscopy, 2nd ed
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