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. Configurational entropy changes per residueChanges in conformational entropy upon binding can also be calculated per residue
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. 8 be tested experimentally? Fluctuations for a chain of length N will lead to cavities that are large enough to allow for the free diffusion of a smaller chain of length nContacts are hierarchical and average topologies are independent of sequence Two residues are said to he in contact if there are at least two atoms (including hydrogen atoms), one from each residue, within a 6-[Angstrom]; distance of each other
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