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. Indeed, the significant stability of GR dimers is illustrated by the fact that no changes in fluorescence emission of this protein take place even in the presence of 2 M urea and at a hydrostatic pressure of 3
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. How the dilatation symmetry of denatured states is broken under folding conditions will depend on a variety of factors including local biases for turns and short stretches of extended or helical conformations, the drive to sequester hydrophohic amino acids, and the achievement of specificity in side-chain packing (103)
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. Analysis of the EV-limit ensembles suggests that the observations of local sequence-specific contacts are not incompatible with the observed power law behavior
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. Freeze denaturation of enzymes and its prevention with additives
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. The spatial resolution of MRI typically ranges between millimeters and hundreds of microns (4,5), whereas MRS-which generates signal from nonwater protons whose concentrations fall far below those of the water protons used in MRI-requires voxel sizes of tens of millimeters for humans to a few millimeters for smaller animals like rodents (6,7)
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. Molecular dynamics of acetylcholinesterase
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. Since pressure does not alter the surface charge or hydration of the membrane, electrostriction effects are not expected to play a significant role, and previous studies of the electrostatic component of the small peptide melittin correlate well with this idea (Teng and Scarlata, 1993)
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