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as in the case of the eyes of animals inhabiting dark caverns
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Similarly, if the genes that control eye degeneration in cave fish also control other, unrelated structures that could confer an advantage to fish living in darkness, pleiotropy could explain the loss of eyes
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EI proteins are composed of two domains (6,7): a proteolytically inert N-terminal (EIN), and a proteolytically unstable C-terminal domain (EIC)
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Interestingly, the characteristics of spectral shapes as observed for BLA and PPA appear rather similar, although BLA shows a red shift and PPA a blue shift upon thermal unfolding
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However, at the relatively high CaM concentration (1 mM) used in the NMR experiments, compared to the nanomolar dissociation constant of the complex, all CaM is in the bound state
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Stereoisomeric discrimination in DNA compaction
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Prefibrillar amyloidogenic oligomers and protofibrils of misfolded TTR were generated in vitro through induction of the molten globule type A-state from acid unfolded TTR through the addition of NaCl
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However, repeating this study for solubilized proteins that were freshly dialyzed to remove detergent gave an apparent K^sub d^ only 10-fold weaker than predicted, suggesting that we may be not be viewing a simple protein-protein association (K^sub d^ ~ 70 nM; Fig
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33 K/min (80 K/h) yields similar CD melting curves (not shown), with the apparent T^sub m^ = 84°C identical to that of intact disks
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Our aim in this work is to take a fresh look at the issue, embracing many simplifications but on this occasion not that of a low dimension of configurational search space
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Segments or regions that are directly involved in intermolecular interactions or that are indirectly affected upon binding: residue F43 of CD4 (code: F43) and the residues of gp120 forming a cavity to hold F43 (code: F43cav), residues of gp120 that form intermolecular hydrogen bonds (code: interHb) and their counterparts in CD4 (code: interHb); see Fig
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These differences were not statistically significant (p > 0
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Daniel died in his dorm room after he took OxyContin to get high, then drank alcohol at a party
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The monkeys that experienced a stressful environment
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How drugs work; basic pharmacology for healthcare professionals, 2d edHow drugs work; basic pharmacology for healthcare professionals, 2d ed
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PRESCRIPTIONS PADDED As influential as advertising drugs to consumers may be, it represents only a small fraction of pharmaceutical companies' promotional efforts
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they're building rules and reimbursement models that disable that structure, or that at least threaten it," said Petri, who is executive vice president of pharmacy and logistics for Kerr Drug
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Journal of Nursing Education
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And if not, they can move on quickly
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Adelson, chairman and chief executive officer of Las Vegas SandsCorp
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Table 1 offers a complete summary of participants' gambling participation
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Our study distinguished between personal control over skill-relevant dimensions of play and over skill-irrelevant dimensions of play
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