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A further increase in quenching efficiency was observed at 7 M GdnHCl (squares, K^sub SV^ = 40 M^sup -1^), indicating that even at 3 M GdnHCl the tryptophan residues of GR were still significantly protected from iodide quenching relative to the fully unfolded protein
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DISCUSSIONMolten globule (MG) folding intermediates have been characterized for a number of proteins (for reviews, see Kuwajima, 1989; Ptitsyn, 1992, 1995)
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It has a role in bone health; as a potential anti-hypertensive agent, calcium plays an important role in weight management and may reduce the risk of certain cancers
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Once thermograms were normalized to protein concentration, a chemical baseline calculated from the progress of the unfolding transition was subtracted
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In short, apoptotic cells must express clear-cut "eat-me" signals (Fig 2, top, A)
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Above that temperature, the MSDs for HuBChE-D^sub 2^O are larger than those for Soman/HuBChE-D^sub 2^O, which remain in a quasiharmonic regime, as shown by their linear dependence on temperature (Fig
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3 shows the theoretical RT^sup n^^sub 1^ curves for a molecule with a correlation time, τ^sup o^^sub m^, of 10 ns with one internal motion, τ^sub if^, ranging between 20 ps and 6 ns, and squared order parameter, S^sup 2^^sub f^, ranging between 0
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The interaction is clearly different from the well-known categories of specific binding by lock-and-key or induced-fit binding, in which the complex in the bound state becomes essentially locked in one conformation
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In this work we explore a novel pathway for generation of prefibrillar aggregates of TTR, which provides important insight into TTR misfolding
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Isotactic polypropylene (IPP) and poly(ethylene-co-vinyl acetate) (EVA) are converted into toners by means of TIPS
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The resulting network of tertiary loop-loop contacts are revealed in a crystal structure of the hairpin ribozyme in its docked conformation (Rupert and Ferre-D'Amare, 2001)
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. These hierarchical distance distributions reflect the so-called dilatation symmetry in the EV limit whereby contact density maps for one protein sequence can be rescaled to obtain the contact density map for another sequence
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. Address reprint requests to Rohit V
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.The objectives of the research [14] reported in this paper are to produce toners using binders with high flexibility (low T^sub g^ and high elongation) and to evaluate the properties of fabrics printed with these toners
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