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The protein concentration used for the studies is 0
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The average shape of a denatured protein is that of a prolate ellipsoid We computed the ensemble-averaged asphericity values for each of the 23 sequences in the EV limit and the resultant data are shown as cross marks in Fig
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Conformational substates in proteins
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We employed the DCVJ probe to investigate its potential use for recognition of misfolded aggregates formed from TTR
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The quenched Trp fluorescence in the presence of ANS and Bis-ANS (Fig
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These results gave a volume change of 34 ± 5 ml/mol
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