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. The fluorescence intensity of the different probes in the presence of the unfolded monomer state is shown in Fig
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. Mikael Lindgren,* Karin Sörgjerd,[dagger] and Per Hammarström[dagger]* Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway; and [dagger] IFM-Department of Chemistry, Linköping University, SE-581 83 Linköping, SwedenSubmitted July 16, 2004, and accepted for publication March 9, 2005
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. The destabilization of the soman-bound unfolded state is, therefore, likely to arise from a decrease in its entropy, as a consequence of certain configurations no longer being available to the unfolded structure due to the presence of the covalently bound inhibitor
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