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Theoretical studies of protein folding
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The orientation and optimization of side chains were carried out in two steps
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The ANS binding test extended to other proteins confirmed a widespread stressed condition of the globular structure in ice, indicating that oligomers' proteins are more susceptible to unfolding than monomers', presumably because the macromolecule can be further destabilized by subunit dissociation
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De Matteis, and A
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Its characteristic features are: i), specific high-affinity binding in the presence of fast exchange, ii), accommodation of a relatively nonmatching and flexible target via exchange between multiple binding alternatives, iii) dimerization of CaM upon target binding, and iv), large-scale (domain) motions on the nanosecond and microsecond timescale
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On solid-like rheological behaviors of globular protein solutions
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20 mg/ml (14 µM monomer) TTR in native (10 mM phosphate, pH 7
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Specifically, the pressure-induced growth of the circular insulin amyloid suggests anisotropic packing within an ambient protofilament
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