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Moreover, resolution-enhancing techniques, such as second derivative and 2D IR, have been shown to be sensitive tools to monitor the sequential events in protein conformational changes by FTIR (27,28,30,38-42)
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A first-principles reassessment of the source of this empirical correlation is mandated
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They were calculated by dividing 5 ppm by the chemical shift span corresponding to the specified rf bandwith and the magnetic field
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The stability of a particular configuration is given by the free energy difference between the folded and unfolded states
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Backbone dynamics of a free and phosphopeptide-complexed Src-2 homology domain studied by ^sup 15^N relaxation
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We also tested the ability of Gα^sub s^ to remain membrane-bound under pressure
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Similar multiphase kinetics of the Gdm-induced unfolding was observed in apoA-1:DMPC disks (Reijngoud and Phillips, 1982) and in apoC-1 disks (unpublished data)
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Recently, ideas as to the generic, polymeric character of amyloids (Fändrich and Dobson, 2002), and the importance of destabilization (or complete unfolding-e
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This precisely exemplifies the general mechanism we have suggested, with the additional feature that one of the hypergutters has become so stabilized (and therefore so populated) that it attracts the label of "intermediate state"
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The model provides an alternative interpretation of the results of protein engineering analysis, and implies that not all contributions to measured Φ-values at the transition state may arise from native-like interactions
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26 BL; mean BD/BL=0
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5-, 1-, and 2-ns block sizes) were used for fitting the standard errors to an exponential function using the xcrvfit software (http:// www
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We thank Sean Burnett, Wendy Eyres, and Suzanne Solven of the BC Ministry of Health for assistance with the collection and interpretation of the data
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Many researchers say hallucinogens were kept out of research labs because of fear generated by drugs like methamphetamines and heroin and the "war on drugs
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Bush about the profits pharmacies make filling Medicaid prescriptions
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--Pharmaceutical Sciences Clinical Pharmaceutical Sciences Social-Administrative Pharmacy* LOUISIANAUniversity of Louisiana at Monroe College of Health Sciences M
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The tough part, Rocco Mediate can handle
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When partition by age of legal wager, 9
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