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5 kbar (data not shown), a pressure at which a large number of protein dimers and higher oligomers have been found to undergo subunit dissociation (Gross and Jaenicke, 1994; Heremans and Smeller, 1998)
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The main conclusion is that analysis of the EV-limit ensembles does not preclude the possibility of occasional close contacts between residues that are distal in sequence
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There are two obvious differences between our approaches
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Stability of EI^sup sc^ as monitored by DSC and thermal denaturations From the spectroscopic results above, it can be concluded that EI^sup sc^ acquired a folded conformation around physiological pH, and that this structure was basically unaltered (exeept for changes in the ellipticity, Fig
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While at this moment the demonstration of a direct role for impaired efferocytosis in disease pathogenesis is in its infancy, we think that it is reasonable to speculate on potential therapeutic approaches
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9 for C3A/C26A, 6
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The Φ angles, recalculated with the smaller anisotropy, were essentially within the error margins of the earlier estimates
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Global structure and dynamics of recombinant human Apolipoprotein CII in complex with SDS micelles: evident for increased helix mobility in the binding/activation site for lipoprotein lipase
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Partitioning the configurational space in this way, and by providing an attractive "gutter", relying on local forces alone, to connect one diffusive subspace to the next, creates the advantageous funnel landscape when the high-dimensional structure is projected into a one- or two-dimensional space
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It is clearer in experiment than the subsequent dimensional reductions because it is the only one that makes significant changes to the radius of gyration of the protein
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In terms of frequency, there were differences in the immunostaining with TGF-[alpha] in both reactive mesothelial proliferations and mesotheliomas, but these differences did not achieve a level of significance (P =
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