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. ) Encouraged by the rough agreement between the theoretical and experimental binding enthalpies, we aimed at extracting the binding entropy from our simulations and at gaining insight into CD4 binding-induced conformational changes in gp120 that are related to entropy changes
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. Likewise, the Mg-binding parameters (K^sup Mg^^sub D^ and n) obtained from the previous trFRET data are also in reasonable agreement with the corresponding values reported here
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