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Jarvis soon decided that the grassroots organizing was too costly
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Goozner examines this quirk and asserts that drug prices aren't based on the actual cost to invent them
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Implications for the design of antiparasitic drugs
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Protein glycosylation is more profuse and structurally more complex than all other types of posttranslational modifications taken together (1-3)
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These interactions will be determined by the specific sequence or, more precisely, by native-state topology
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When compared with the EIC^sup tt^
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Lithium, sodium, potassium, rubidium, and cesium chlorides were purchased from Wako Pure Chemical Industries
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In contrast, when there are packing voids, the stability of membrane binding of a protein under pressure will depend on its ability to deform under pressure to fill in voids and reduce the volume
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Originally conceived as a kinetic theory in which a nucleus of native structure corresponds to the transition-state for folding, the picture now also encompasses the hierarchical folding routes of the diffusion-collision model
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It also delivers improved tool life and surface finish even though tool life is often the reason why wet machining is applied
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The process parameters (such as solvent, concentration, cooling rate) used to produce nylon particles were quite different from those we use here to produce IPP and EVA toners
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Subsequently, the native tertiary structure is formed through a slow (rate-limiting) conformational search and/or consolidation of specific metal-ion binding sites
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Barr Pharmaceuticals' Plan B, a nonabortifacient morning-after pill, has been languishing in FDA limbo since 2003, despite the absence of any credible safety concerns
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The FDA has also found companies that sell counterfeit pet products, make fraudulent claims, dispense prescription drugs without requiring a prescription, and sell pet drugs that have expired
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and the metabolic fate of theses substances in humans
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AMost of these 15 stories were previously published either in literary magazines or such targeted-audience periodicals as Asimov's Science Fiction and Seventeen
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I KNEW I HIT ROCK BOTTOM WHEN I AWOKE TO FIND MY DOG EATING MY FOOT
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ACKNOWLEDGEMENTSThe authors would like to thank Bradley Wood, Chrystal Pierce, Anette Herrera and Shoreh Biazar-Sadri for their help with data collection
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The results indicated a greater level of participation in gambling activities for intrinsic reasons than for extrinsic ones
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The Gambling Motivation Scale (GMS) is a 28-item questionnaire which measures intrinsic and extrinsic motivation among gambling participants (Chantal, Vallerand, & Vallieres, 1994)
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A fourth is in the works
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Paradoxes of gambling behavior
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., manufacturer of dietary supplements, followed this concept twice with success recently
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. In addition, the peak corresponding to tryptophan emission displayed a significant red-shift to [lambda]^sub max^ ~ 334-339 nm
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. Since no high-resolution structure of ACYI is available, all of the Trp fluorophores (Classes A and S, I, II, and III) defined previously (34) were included in the fitting procedure
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. two peaks with different thermodynamical properties are observed, one corresponding to EIN (with pH-independent T^sub m^, values) and a second corresponding to EIC (with pH-dependent T^sub m^-values) (6)
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. which suggest that small rearrangements occurred upon binding, as further confirmed by quenching fluorescence and trypsin digestion experiments
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. The impact of aggregation on fluorescence emission spectra To investigate how fluorescence emission spectra are affected by aggregation we measured the aggregation directly by the use of elastic light scattering and we analyzed unfolding transitions under different conditions which lead to a different extent of protein aggregation
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. The lower value for the Bis-ANS case is (at least) partially due to the shorter lifetime that will truncate the measurement since the rotational correlation time is considerably longer than the decay lifetime
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.Studies on the pathogenic amyloidogenic self-assembly of proteins are showing that different transient morphological forms of aggregates have varying neurotoxicity levels (e
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. 5, in which we assume that the transition state energy depends on denaturant concentration in the same way as the gutter energy, for the sake of illustration
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., unequal elevations) which necessitated that the data be fitted with a parallel-lines multiple linear regression model (Fig
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., under conditions used for generating the FRET histograms in this article)
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. The SL 2WJ shows a small but marked peak shift to higher E as Mg^sup 2+^ concentration is increased (Fig
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. For comparison, we also overlay histograms for twofold slower and faster rate constants (dashed lines), with the equilibrium constant maintained at 3
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. Type 2 RP was applied to the NSAIDs in November 1995
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., director of the GenEthics Unit at the National Human Genome Center, says despite BiDil's initial success, African Americans should not be treated as a monolith when it comes to drug therapy
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. Symptoms of hepatotoxicity, such as nausea, vomiting, and abdominal pain, may not appear until more than 24 hours post ingestion, but liver damage--and even death--may occur if the antidote n-acetylcysteine (or NAC) is not administered within eight hours after ingestion
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. Most suicidal patients present within four hours of ingestion and, therefore, receive the NAC treatment in a timely manner
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. DTC advertising for a particular drug tends to increase, at least slightly, sales of that medication and similar drugs, she says
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., on-site pharmacy is independent Oakland Pharmacy, which has been in business for more than 25 years
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.--Pharmaceutical Science* MICHIGANUniversity of Michigan College of Pharmacy Ph
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