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Since K^sub SV^ equals the product of the bimolecular quenching rate constant (k^sub q^) and the excited-state lifetime of the fluorophore ([tau]), the value of K^sub SV^ obtained from steady-state fluorescence measurements is dependent on the average lifetime
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For small n, we obtain softer repulsive potentials
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The average shape of a denatured protein is that of a prolate ellipsoid We computed the ensemble-averaged asphericity values for each of the 23 sequences in the EV limit and the resultant data are shown as cross marks in Fig
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5 mM PEP and 5 mM Mg^sup 2+^), and every digestion was repeated three times
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that the large amphipathic surface in the dimer interface could be exposed to solvent upon monomer formation; furthermore, there is a network of aspartic residues involved in salt bridges at the dimeric interface (Fig
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The impact of aggregation on fluorescence emission spectra To investigate how fluorescence emission spectra are affected by aggregation we measured the aggregation directly by the use of elastic light scattering and we analyzed unfolding transitions under different conditions which lead to a different extent of protein aggregation
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The concentration of ANS, as determined by absorbance at 370 nm, using ε^sub 370^ = 6800 M^sup -1^Cm^sup -1^ (in methanol), ranged between 10 and 450 µM although in most experiments the upper limit was 320 µM
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The tiniest seedlike forms appear within the first minute of incubation at either temperature
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Amyloid nucleation and hierarchical assembly of Ure2p librils
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The upper stripe developed from the tip of the snout and the lower one began below the eye, both extending to the anterior caudal peduncle
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The stable intermolecular hydrogen-bond network (166 and 130 atoms for CD4 and gp120, respectively; for details see Table 1)
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Chemokine receptors as HIV-1 co-receptors: roles in viral entry, tropism, and disease
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Claritin, Schering-Plough's popular antihistamine, has been over the counter for years; Clarinex, a virtually identical drug from the same maker, is prescription-only
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Schering-Plough had been touting the safety of Claritin for years; the company's ads explicitly state that the side effects are those of a sugar pill
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The FDA's hearings on statins demonstrate how the agency weighs factors far removed from the side effects of a drug itself
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About one-quarter of the savings that Pharmacare realized from the introduction of RP represented additional costs to nonexempt patients who elected to use higher priced NSAIDs
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Pharmacare savings were partially offset by increased total patient spending of $92,000 and $820,000 annually after the introduction of Type 1 and Type 2 RP, respectively (Table 5)
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[ILLUSTRATION OMITTED](L to R) Wal-Mart's Bob Dufour with Natalie Baker and Jim Liebman from AstraZeneca
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21% of those under 21 were classified as potential pathological gamblers as compared to 14
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