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RESULTS In this work, we focus on two-state proteins because the hypothesis is that only two well-defined macrostates-native and highly denatured states-are accessible to these systems (67-70)
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that the large amphipathic surface in the dimer interface could be exposed to solvent upon monomer formation; furthermore, there is a network of aspartic residues involved in salt bridges at the dimeric interface (Fig
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Zaccai*||* Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale, Grenoble, France; [dagger] Centre de Recherches du Service de Santé des Armées, Unité d'Enzymologie, La Tronche, France; [double dagger] Institut de Pharmacologie et Biologie Structurale, Toulouse, France; § Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland; ¶ Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel; and || Institut Laue-Langevin, Grenoble, FranceSubmitted February 9, 2005, and accepted for publication June 30, 2005
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The PairoVET sampler, a Bongo-type version of the CalVET, was fitted with two 200-[micro]m mesh nets to sample fish eggs (Smith et al
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In addition, the head and the teeth patch of the vomer are quadrangulate in Pinguipes and triangular in Pseudopercis (Herrera and Cousseau, 1996)
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On extremely busy days when numerous charter boats were fishing, all mature females were collected, but immature fish were not measured
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major, because the size was similar to that of P
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Thus, we believe that the strong expression of EGFR on cell membranes may be related to promoted cell proliferation in malignant mesothelioma
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.One of the best-documented cases of pleiotropy is the gene associated with sickle-cell disease
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. For PPA, which already exposes tryptophan residues to the protein surface in the folded state, a blue shift of the emission spectrum occurs upon thermal unfolding (see Fig
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. The stability of these mutants is ~3 kcal/mole lower relatively to the WT (20-22), and the internal flexibility of the polypeptide is considerably larger, particularly with I7S and F110S (18)
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