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These results indicate a multistate folding pathway for GR and suggest a critical role of molten globule monomers in the correct dimerization of GR
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The conformation changes cooperatively from native state to random coil between pH = 5 and 3
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As the temperature was increased, the intensity of the hands from the native secondary structures decreased, and two new bands (1618 and 1682 cm^sup -1^) appeared at temperatures above 70°C
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The protein concentration used was 0
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Hence, the first transition is related to the dissociation of the tetrameric unit to constituent monomers, whereas the second one represents opening up of the individual subunits
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CONSEQUENCES OF DEATH AND REMOVALBurying the BodiesThe most immediate consequence of efferocytosis is the physical removal of apoptotic cells before membrane permeability sets in, thus preventing the release of potentially toxic intracellular contents
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4 ms was used for (180 µm)^sup 3^ voxel spectra, and TE = 6
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In oscillatory shear experiments, the storage modulus crossed the loss modulus at concentrations of 54% w/w, an indication of the approaching glass transition
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The intrinsic quenching of molecular rotors makes them sensitive to intrinsic rotational relaxation, which is slowed down during binding to aggregated protein
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The CD spectrum of apoA-2:DMPC disks (Fig
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This, in fact, is direct evidence supporting the model of amyloids as waterfilled nanotubes (Perutz et al
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Irregularly shaped particles that could not be divided into spherical particles were produced for cases D and E (similar cooling rates)
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The FRET efficiency histograms described in this article were generated by using a two-channel data collection mode to simultaneously record donor and acceptor signals as a function of time, with a time resolution of 0
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Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction
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126 -2,895 23,228OpiatesAverage monthly effect 492 <
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The work grows out of discoveries in the past 2 years that several Gyps vulture species have almost vanished from India and Pakistan because residues of the anti-inflammatory drug dielofenac in dead farm animals ruin the kidneys of the scavenger birds (SN: 2/4/06, p
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The Journal of General Psychology 122, 253-269
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