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. For each of the amino acid sequences shown in Table 1, ensemble averages and conformalional distributions were obtained from an ensemble with a sample size of 10^sup 4^ and the ensembles were generated as discussed above
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. This is not, of course, to suggest that the path is unique, since: 1), a large fraction of each subdimension may be explored; 2), the path is at each stage reversible; 3), degrees of freedom inessential to the current dimensional reduction are not "frozen" but are freely exploring their configurations; and 4), the nondiffusive "zipper" dimensions describing the local folding of secondary structure are perpetually exploring their own configurational space rapidly and cooperatively with the slow dimensions
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. AIP Series in Polymers and Complex Materials
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. Several general predictions result: 1), intermediate subspaces of configurations will always be visited; 2), specific but nonnative interactions may be important in stabilizing these low-dimensional diffusive searches on the folding pathway, as well as native interactions; 3), sequential barriers will commonly be found, even in "two-state" proteins; 4), very early times will show characteristic departures from single-exponential kinetics; and 5), contributions of nonnative interactions to Φ-values and "Chevron plots" are calculable, and may be significant
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