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American Institute of Physics, New York
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Our approach suggests that thermodynamical analysis might reveal subtle conformational changes
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no histidine residue was near to any of the tyrosine residues or Trp^sup 461^
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The statistical proof of discreteness of tryptophan classes in proteins
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The methine peak at 5
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(15) and references therein), MD simulations (16), and incoherent neutron scattering (17)
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Presumably, the wetting force represents the driving force toward the wetting as well as good bonding
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Hence, there are four hinge regions in the CaM dimer
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In comparison, the misfolded aggregated states from A-state TTR show a much stronger quantum yield for Bis-ANS than for ANS (Fig
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Borén, and U
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, 1981), lipid binding increases the helix content in apoA-2 to ~64%
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Only spatially-local interactions are required to direct the folding toward the native state in reasonable times
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Anal-fin membranes were more pigmented than those of the dorsal fin
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Western Australia Press, Nedlands, Western Australia, Australia
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The EVA 40% film was not measured because the polymer was too flexible for proper clamping of the sample in the test holder
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The quasi-docked conformation interconverts rapidly with an extended structure, giving rise to continuous peak shifts with added Mg^sup 2+^, as well as pronounced asymmetry and broadening in the FRET efficiency histogram at high Mg^sup 2+^ concentrations
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In a more recent survey of 643 U
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These results are consistent with those obtained in a study conducted by Damush et al
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. The heat flow versus temperature profile of ACYI contained an asymmetric positive peak arising from an exothermic transition (Fig
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. In high concentrations of denaturants, proteins behave like polymers in a good solvent and ensembles for denatured proteins can be modeled by ignoring all interactions except excluded volume (EV) effects
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. In our EV model, there is only one free parameter, namely the exponent n
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. This point has been made recently by Dima and Thirumalai (66) who carried out a systematic study of asymmetry in the shapes of folded proteins
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. To generate ensembles that are sell-avoiding, either build-up procedures that screen for long-range hard-sphere steric overlap or Monte Carlo simulations are used
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. In the modeled structure, there was a long α-helix that is supposed to serve as a linker to the EIC domain
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. As the EIN^sup st^ and EIN^sup ec^ have pH-indepcndent T^sub m^ values close to 328 K (4,5), and thus similar to the T^sub m^ value measured in EI^sup sc^ (Table 2)
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. NMR and Its Applications to Living Systems
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. The CaM dimer is created by the tip of the N-terminal domain of one CaM monomer contacting the tip of the C-terminal domain of the other CaM
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., 2000), and this remains in accordance with a threedimensional model proposed for insulin amyloid fibrils (Jimenez et al
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. Conformational variations in an infectious protein determine prion strain differences
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. The pelvic fin was large and slightly shorter than the pectoral fin, whose margin was rounded
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. jugularis larvae in some relevant features:* The head had no spines and was less rotund, rather moderate instead of large (HL ranged from 0
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., of bound and unbound states, whereas analysis of the single trajectories only provides information about the extent of the respective conformational spaces, and not about their degree of overlap
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. T^sub g^ and initial modulus were determined by dynamic mechanical analysis (DMA, Seiko SII DMS 210)
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