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You're a bigger fish
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, 1988) and facilitation of protein lysosomal degradation (Ptitsyn, 1992)
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8, both plots revealed that there are two linear segments that deviated at a temperature of around 68°C, and each straight line reflected a two-state process
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CONCLUSIONS We have used an atomistic EV model, developed in previous work, to show that it is computationally tractable to generate accurate conformational ensembles for proteins in the EV limit
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These changes led to burial of the Tip and/or Tyr and other regions susceptible to trypsin digestion
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The fluorescence emission, collected at 90° from the excitation, is dispersed by a 0
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In this report we present the backbone dynamics of the CaM dimer bound to the dimeric SEF2-1mp
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Residues 14, 19, 51, 55, 76, 92, and 118 show a relatively strong decrease in exchange rate upon change in temperature (f = 0
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Nuclei that are influenced by chemical exchange have been shown to correlate with residues known to be critical for protein interactions and enzymatic activity (39,40, 41,42,43,44)
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However, viscosity alone does not give the complete picture, since we also note a significant blue shift in the fluorescence maximum when bound to amyloid fibrils and to prefibrillar misfolded oligomers
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, Hanau, Germany) was the anti-blocking agent, and 3- lauramidopropyl trimethyl ammonium methyl sulfate (Cytec Industries Inc
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major (20 April, 1995) could react with the antibodies obtained as clearly as the recently collected eggs of P
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Likewise, the Mg-binding parameters (K^sup Mg^^sub D^ and n) obtained from the previous trFRET data are also in reasonable agreement with the corresponding values reported here
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Bader, PhD, Professor of Mechanical EngineeringMedical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
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The study was approved by the Food and Drug Administration in December, and the Drug Enforcement Administration was expected to issue the required federal license after a March visit to the research site
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Other projects supported by the group include psychiatrist Charles Grub's psilocybin research with terminal cancer patients at UCLA; Charleston, South Carolina, psychiatrist Michael Mitohefer's study of MDMA as a treatment for posttraumatic stress disorder; and University of Arizona at Tucson psychiatrist Francisco Moreno's study of psilocybin as a treatment for obsessive compulsive disorder
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