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. The secondary structure of EI^sup sc^ upon binding was not largely affected (Table 4), but there were subtle changes in the stability of the protein (Table 3)
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. Processive enzymes, when sliding along their targets (50), have the closest similarity to CaM:SEF2-1mp binding
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. This is both natural and necessary, since data from kinetic experiments do just the same, but there is a danger in overlooking aspects of folding that rely essentially on the presence of many degrees of freedom
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. W/d=missing data
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. The aromatic chromophore 1-anilino-8-naphthalene sulfonate (ANS) is feebly fluorescent in water, but its spectrum is blue shifted and its intensity is dramatically increased in nonpolar solvents or when it binds to nonpolar sites of proteins (4,5; for a general review, see Slavik (6))
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.To see how this works, we suppose at first that the d ~ O(10^sup 2^) dimensions of the full folding space are now arranged sequentially so that diffusive searches in one dimension at a time allow the protein to find "gateways" into the next subspace (we will see how this may arise naturally in a physical way below)
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