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. Despite the large amounts of ACYI that exist in mammalian kidney and liver, the reactivation of ACYI is particularly difficult in vitro (19-21), which suggests that the folding of ACYI in vivo might be assisted by the possible intracellular molecular chaperones and/or osmolytes
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. Since conformational fluctuations are uncorrelated in a chain devoid of interactions, it is impossible to find large cavities (a > 5 [Angstrom]) within the interior of a freely rotating chain
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. 9, which plots the probabilities, P^sub oa^(r = U), of finding cavities of different sizes at the ensemble-averaged center-of-mass as a function of cavity radius a
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. Beyond this length scale, all internal distances scale with sequence separation in accordance with the standard power law for proteins in a good solvent
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