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5 B clearly indicates that the change of the band at 1628 cm^sup -1^ was the dominant event at temperatures below 66°C, whereas the asynchronous plot was dominated by noise and no crosspeaks could be identified at a similar position in the synchronous plot
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Validity of the "two-state" hypothesis for conformational transitions for proteins
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(9) compared root-mean-square atomic fluctuations of free AChE and of the AChE-huperzine A complex by a 1-ns MD simulation
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The plots can be interpreted in analogy to Guinier plots of polydisperse dilute solutions: In SAS experiments, linear regimes can be assigned to populations of distinct radii of gyration R^sub g^, provided Q*R^sub g^ Whereas at low temperatures, intensities decreased linearly over the whole Q-range measured for all samples, a more or less pronounced kink appeared in the Guinier plots above ~200 K (Fig
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To enable conformational characterization of protein isolated from biological specimens such as samples from patients, noncovalent recognition using extrinsic dyes is necessary
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ApoA-2 has particularly large apolar helical faces (50% of the surface as compared to ~30% in apoA-1 and apoC-1) which, along with higher hydrophobicity of these faces, is thought to account for stronger association of apoA-2 with HDL (Brasseur et al
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In consequence there are contributions to measured Φ-values that arise from this "preexponential" effect
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The entropy analysis was therefore performed on the last 8 ns of each simulation, using molecular configurations that are two picoseconds apart
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Single-molecule methods represent an excellent tool to decipher the complexity of RNA folding processes, which generally proceed via intermediates and multiple pathways
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We report the case of a 10-year-old girl who was accidentally shot by a BB gun
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ALMOST EVERY PARENT I KNOW LIES TO THEIR KIDS ABOUT THEIR OWN PAST AND PRESENT DRUG USE
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In the months since the PhRMA meeting, where Weldon was elected to head the trade association's board of directors, companies such as Johnson & Johnson and AstraZeneca have introduced new television ads that include recitations of circumstances in which patients shouldn't use the companies' products
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In the case of cancer, Professor Croce points out that "All vertebrates are susceptible to cancer," and so they can be used as "natural experimental models" by meticulous observation of how the disease develops in them spontaneously in the natural environment (p
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Data AnalysesDescriptive statistics were used to characterize the sample
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When asked to indicate their favorite form of gambling, machine play (video poker or slot for example) was first for both groups (49
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