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. The strong positive correlation between folding rates and contact order implies that folding rates depend only on the end point, i
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. These findings seem to support the hypothesis that both domains must suffer large conformational rearrangements when they are joined
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. For if a residue contributes via nonnative interactions to the stable hypergutter that concludes the dominant (longest) diffusive search, then mutations to that residue will affect the folding rate, even though it does not necessarily possess any native contacts at the transition state
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