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* Reino: We have what we call a Resource Consumption Initiative
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. The curves from the diluted solution (data not shown) were similar to those presented in Figs
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. It is worth mentioning here that our efforts to cleave the intact glycoprotein using α-mannosidase failed repeatedly
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. Irrespective of chain length and sequence, the contact densities follow a hierarchical pattern whereby near-neighbor residues have a higher probability of being spatially proximal
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. Estefanía Hurtado-Gómez,* Gregorio Fernández-Ballester,* Harald Nothaft,[dagger] Javier Gómez,* Fritz Titgemeyer,[dagger] and José Luis Neira*[double dagger] * Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain; [dagger] Lehrstuhl für Mikrobiologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; and [double dagger] Biocomputation and Complex Systems Physics Institute, Zaragoza, Spain Submitted October 31, 2005, and accepted for publication March 7, 2006
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. (41) The importance of this response is suggested by the well-known ability of HGF to enhance epithelial cell proliferation and to facilitate lung regeneration
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. Third, in contrast to the reversible unfolding of lipid-free protein (indicated by the agreement between the heating and cooling CD curves in Fig
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. This suggests that two slightly different conformational spaces are sampled in the free and complex forms of the molecule, representing a situation of case A (Fig
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. In fact, the 3WJ ribozyme does not fold significantly (to a compact structure) in the absence of loop A, indicating that the loops are more important than the junction for tertiary folding in this case
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. SUPPLEMENTARY MATERIALThe following supplementary material is available for this article online: TABLE S1
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. The Cu-Sn reaction is selective15 and therefore a very rough scalloplike Cu^sub 6^Sn^sub 5^ IMC layer was detected
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