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Analysis of difference contact maps suggests that to fold, the dilatation symmetry in the EV limit is broken by weakening specific nonnative local contacts
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In a well-known example, the higher cationicity of spermine^sup 4+^ compared to spermidine^sup 3+^, which evidently makes spermine bind more strongly to negatively charged DNA, determines the higher DNA compaction potential of spermine (Takahashi et al
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Such an alternative scenario of fibrillar self-assembly may, in the end, lead to morphologies with a screwlike outlook, otherwise postulated to result from the hierarchical twisting
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In practice, of course, the dimensionality of the folding space is enormous
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This is because the rate-determining diffusive searches will in general be completed only when a topological, as well as a spatial, constraint in the final native state is satisfied for the first time
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Mean ([+ or -] SE), range and number ofobservations are shown in the table
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Periodo diciembre 2000 a marzo-abril 2001
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(11)There has been some discussion as to whether BB and pellet fragments in the sinuses should be removed
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After 48 hours the cells had formed pellets, which were randomly subdivided into two groups
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. For experiments involving PEP, control scans were acquired with PEP added to buffer versus buffer in the reference cell, and baselines were found to be the same as in buffer-buffer baselines, suggesting that under these conditions hydrolysis of PEP during heating was not significant
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